Effect of neurostimulation on cognition and mood in refractory epilepsy.

Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to treat. For patients with refractory epilepsy who are not candidates for resection, neurostimulation, the electrical modulation of epileptogenic brain tissue, is an emerging treatment alternative. Several forms of neurostimulation are currently available, and therapy selection hinges on relative efficacy for seizure control and amelioration of neuropsychiatric comorbidities. Here, we review the current evidence for how invasive and noninvasive neurostimulation therapies affect mood and cognition in persons with epilepsy. Invasive therapies include vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). Noninvasive therapies include trigeminal nerve stimulation (TNS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). Overall, current evidence supports stable cognition and mood with all neurostimulation therapies, although there is some evidence that cognition and mood may improve with invasive forms of neurostimulation. More research is required to optimize the effects of neurostimulation for improvements in cognition and mood

Measurement of ultralow injection current to polymethyl-methacrylate film

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Application of the Spiritual Intelligence Self-Report Inventory (SISRI-24) Among Hong Kong University Students

The aim of this study was to examine the psychometric properties of the Chinese version of the Spiritual Intelligence Self-Report Inventory (SISRI-24). Two hundred thirteen undergraduate students in Hong Kong completed the Chinese SISRI-24, the Meaning of Life Questionnaire, the Metapersonal Self-Construal Scale, and the Satisfaction with Life Scale to allow examination of internal reliability and construct validity. Confirmatory factor analysis was also performed to examine whether the model of King and DeCicco (2009) fit our data. Our results indicated that the full scale of the Chinese SISRI-24 and its four subscales had acceptable internal reliability. The results also showed a positive relationship between spiritual intelligence and metapersonal self-construal. However, no significant relationship was reported between spiritual intelligence and life satisfaction. As such, construct validity was low to moderate. This study can be considered a foundation for understanding and measuring spiritual intelligence among undergraduate students in Hong Kong. Future research directions are suggested

Hand, foot and mouth disease in an immunocompetent adult due to Coxsackievirus A6

Hand, foot and mouth disease most commonly occurs in children less than 10 years old, but can occur in immunocompetent adults. We describe a 37-year-old immunocompetent man who presented with multiple painful papules and vesicles on his palms and feet together with vesicles inside the mouth. Real-time polymerase chain reaction revealed Coxsackievirus A6 in the vesicle fluid from the feet, throat swab, and rectal swab. Since the disease is highly contagious, to contain the infection it is prudent to recognise that hand, foot and mouth disease can occur in immunocompetent adults.published_or_final_versio

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

Developing a Holistic Fire Risk Assessment Framework for Building Construction Sites in Hong Kong

Amongst all types of construction accidents, industrial practitioners tend to pay less attention to the prevention of fires at construction sites.  Although fires may not occur frequently on construction sites, statistics show that when they do, the consequences are very serious; involving fatalities, injuries, serious project delays and financial loss.  There are many reasons why fires occur on sites, but a simple lack of awareness of the risks of fire is a major contributor.  Fire risk assessment is not commonly performed on sites.  Hence, it is believed that an appropriate assessment method for evaluating potential fire risk is required in order to improve the awareness of fire risk on construction sites.  This paper reports on the key findings of a research project which aims to develop a comprehensive, objective, reliable, and practical fire risk assessment framework for building construction sites based in Hong Kong.  A comprehensive list of those factors (or conditions) which may constitute a fire risk was compiled using desktop research and structured face-to-face interviews with experienced site personnel.  This list of factors was then used to develop a questionnaire survey form and the Reliability Interval Method (RIM) was used to analyse the survey results and determine the relative importance and rankings of the various fire risk factors at a broad level and risk sub-factors at a detailed level.  It was found that the fire risk factor of “Fire Services Equipment and Installations” has the greatest impact on construction site fire safety, with “Means of Escape in Case of Fire” being the second, and “Attitude of Main Contractor towards Fire Safety” being the third.  In fact, it is the main contractor who plays the pivotal role in maintaining construction site fire safety, which is in line with the high ranking given to the fire risk factor of “Attitude of Main Contractor towards Fire Safety”.  The proposed fire risk assessment framework can be used to develop a useful checklist for assessing the overall level of fire risk for a construction site, and to identify any areas needing improvement.  Although the fire risk assessment framework was developed locally in Hong Kong, the research methodology could be replicated in other countries to produce similar frameworks for international comparison.  Such an extension would aid the understanding of the management of fire risk on construction sites and help discover differences between countries

Cosmic ray feedback in the FIRE simulations: constraining cosmic ray propagation with GeV gamma ray emission

We present the implementation and the first results of cosmic ray (CR) feedback in the Feedback In Realistic Environments (FIRE) simulations. We investigate CR feedback in non-cosmological simulations of dwarf, sub-$L\star$ starburst, and $L\star$ galaxies with different propagation models, including advection, isotropic and anisotropic diffusion, and streaming along field lines with different transport coefficients. We simulate CR diffusion and streaming simultaneously in galaxies with high resolution, using a two moment method. We forward-model and compare to observations of $\gamma$-ray emission from nearby and starburst galaxies. We reproduce the $\gamma$-ray observations of dwarf and $L\star$ galaxies with constant isotropic diffusion coefficient $\kappa \sim 3\times 10^{29}\,{\rm cm^{2}\,s^{-1}}$. Advection-only and streaming-only models produce order-of-magnitude too large $\gamma$-ray luminosities in dwarf and $L\star$ galaxies. We show that in models that match the $\gamma$-ray observations, most CRs escape low-gas-density galaxies (e.g.\ dwarfs) before significant collisional losses, while starburst galaxies are CR proton calorimeters. While adiabatic losses can be significant, they occur only after CRs escape galaxies, so they are only of secondary importance for $\gamma$-ray emissivities. Models where CRs are ``trapped'' in the star-forming disk have lower star formation efficiency, but these models are ruled out by $\gamma$-ray observations. For models with constant $\kappa$ that match the $\gamma$-ray observations, CRs form extended halos with scale heights of several kpc to several tens of kpc.Comment: 31 pages, 26 figures, accepted for publication in MNRA